Genetic analysis of an influenza B virus isolated from a patient with encephalopathy in Japan
Identifieur interne : 001879 ( Main/Exploration ); précédent : 001878; suivant : 001880Genetic analysis of an influenza B virus isolated from a patient with encephalopathy in Japan
Auteurs : Kyoko Shiraishi [Japon] ; Stephen E. Lindstrom [Japon] ; Takehiko Saito [Japon] ; Masayoshi Shinjoh [Japon] ; Reiko Nerome [Japon] ; Sadayuki Funatsumaru [Japon] ; Kuniaki Nerome [Japon]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2001-11-01.
English descriptors
- Teeft :
- Abbreviation, Accession numbers, Acid, Acid change, Acid changes, Acid substitution, Acid substitutions, Acids nucleotides, Acute encephalopathy, Acute necrotizing encephalopathy, Amino, Amino acid change, Amino acid changes, Amino acid differences, Amino acid sequences, Amino acid similarities, Amino acid substitutions, Amino acids, Comparative analysis, Different subtypes, Encephalitis, Encephalopathy, Encephalopathy virus, Epidemic viruses, Evolutionary mechanisms, Evolutionary pattern, Gene, Genetic characterization, Genetic reassortment, Hemagglutinin, Hemagglutinin gene, High levels, High nucleotide, Infectious diseases, Internal genes, Lindstrom, Lineage, Liver enzyme activity, Many cases, Matrix protein, Medical science, Minor clade, National institute, Nerome, Neurological complications, Neurological sequelae, Normal range, Nucleotide, Nucleotide substitutions, Open arrows, Other epidemic strains, Other epidemic viruses, Other viruses, Phylogenetic, Phylogenetic analysis, Phylogenetic trees, Present study, Recent epidemic viruses, Recent viruses, Recent years, Same epidemic season, Same season, Study sequence, Substitution, Total number, Typical symptoms, Victoria lineage, Virol, Virology, Virus, Virus encephalitis, Virus encephalopathy, Virusassociated encephalitis, Yamagata lineage.
Abstract
An influenza B virus, B/Saga/S172/99 (SAG99), was isolated from the nasopharynx of a patient with encephalopathy/encephalitis in Japan in 1999. To clarify the molecular characteristics of this virus, detailed analysis of the gene segments coding for the hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), matrix protein (M) and non‐structural protein (NS) was undertaken. All five genes of SAG99 showed high nucleotide and predicted amino acid similarities with those of recent non‐encephalopathic strains isolated in the same epidemic season. Subsequent phylogenetic analysis revealed that all five gene segments of SAG99 analyzed in the present study were most similar to those of the recent Yamagata/16/88‐like viruses. The hemagglutinin and neuraminidase proteins of SAG99 were each distinguished from those of recent epidemic strains by one characteristic amino acid substitution. These substitutions were not found in the previously reported encephalopathy/encephalitis‐derived influenza B viruses, and we could not find any common characteristic amino acid changes in SAG99 and these viruses. Similarly, among the internal proteins studied, only the M2 protein of SAG99 was found to contain a single novel amino acid change when compared with other recent isolates. Thus, it was apparent that SAG99 contained very few amino acid differences when compared with other epidemic viruses. The association of recent B/Yamagata/16/88‐like viruses with encephalitis/encephalopathy observed in the present study and previously suggest that these viruses may have a higher potential for causing neurological complications in certain individuals. J. Med. Virol. 65:590–597, 2001. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.2077
Affiliations:
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Lindstrom</name></author><author><name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name></author><author><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name></author><author><name sortKey="Nerome, Reiko" sort="Nerome, Reiko" uniqKey="Nerome R" first="Reiko" last="Nerome">Reiko Nerome</name></author><author><name sortKey="Funatsumaru, Sadayuki" sort="Funatsumaru, Sadayuki" uniqKey="Funatsumaru S" first="Sadayuki" last="Funatsumaru">Sadayuki Funatsumaru</name></author><author><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3E233AC5EDFB48B07BC69A48F141178C70CECCEA</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1002/jmv.2077</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-MZCN39WX-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000715</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000715</idno><idno type="wicri:Area/Istex/Curation">000715</idno><idno type="wicri:Area/Istex/Checkpoint">000706</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000706</idno><idno type="wicri:doubleKey">0146-6615:2001:Shiraishi K:genetic:analysis:of</idno><idno type="wicri:Area/Main/Merge">001919</idno><idno type="wicri:Area/Main/Curation">001879</idno><idno type="wicri:Area/Main/Exploration">001879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Genetic analysis of an influenza B virus isolated from a patient with encephalopathy in Japan*</title><author><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Infectious Diseases, the University of Tokyo Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Current Address: Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Correspondence address: Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4‐6‐1 Shirokanedai, Minato‐ku, Tokyo108‐8639</wicri:regionArea><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Lindstrom, Stephen E" sort="Lindstrom, Stephen E" uniqKey="Lindstrom S" first="Stephen E." last="Lindstrom">Stephen E. Lindstrom</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><affiliation wicri:level="3"><country 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Kantō</region></placeName></affiliation></author><author><name sortKey="Funatsumaru, Sadayuki" sort="Funatsumaru, Sadayuki" uniqKey="Funatsumaru S" first="Sadayuki" last="Funatsumaru">Sadayuki Funatsumaru</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Saga Prefectural Institute of Health, Saga</wicri:regionArea><wicri:noRegion>Saga</wicri:noRegion></affiliation></author><author><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology I, National Institute of Infectious Diseases, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">65</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="590">590</biblScope><biblScope unit="page" to="597">597</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-11-01">2001-11-01</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abbreviation</term><term>Accession numbers</term><term>Acid</term><term>Acid change</term><term>Acid changes</term><term>Acid substitution</term><term>Acid substitutions</term><term>Acids nucleotides</term><term>Acute encephalopathy</term><term>Acute necrotizing encephalopathy</term><term>Amino</term><term>Amino acid change</term><term>Amino acid changes</term><term>Amino acid differences</term><term>Amino acid sequences</term><term>Amino acid similarities</term><term>Amino acid substitutions</term><term>Amino acids</term><term>Comparative analysis</term><term>Different subtypes</term><term>Encephalitis</term><term>Encephalopathy</term><term>Encephalopathy virus</term><term>Epidemic viruses</term><term>Evolutionary mechanisms</term><term>Evolutionary pattern</term><term>Gene</term><term>Genetic characterization</term><term>Genetic reassortment</term><term>Hemagglutinin</term><term>Hemagglutinin gene</term><term>High levels</term><term>High nucleotide</term><term>Infectious diseases</term><term>Internal genes</term><term>Lindstrom</term><term>Lineage</term><term>Liver enzyme activity</term><term>Many cases</term><term>Matrix protein</term><term>Medical science</term><term>Minor clade</term><term>National institute</term><term>Nerome</term><term>Neurological complications</term><term>Neurological sequelae</term><term>Normal range</term><term>Nucleotide</term><term>Nucleotide substitutions</term><term>Open arrows</term><term>Other epidemic strains</term><term>Other epidemic viruses</term><term>Other viruses</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic trees</term><term>Present study</term><term>Recent epidemic viruses</term><term>Recent viruses</term><term>Recent years</term><term>Same epidemic season</term><term>Same season</term><term>Study sequence</term><term>Substitution</term><term>Total number</term><term>Typical symptoms</term><term>Victoria lineage</term><term>Virol</term><term>Virology</term><term>Virus</term><term>Virus encephalitis</term><term>Virus encephalopathy</term><term>Virusassociated encephalitis</term><term>Yamagata lineage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An influenza B virus, B/Saga/S172/99 (SAG99), was isolated from the nasopharynx of a patient with encephalopathy/encephalitis in Japan in 1999. To clarify the molecular characteristics of this virus, detailed analysis of the gene segments coding for the hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), matrix protein (M) and non‐structural protein (NS) was undertaken. All five genes of SAG99 showed high nucleotide and predicted amino acid similarities with those of recent non‐encephalopathic strains isolated in the same epidemic season. Subsequent phylogenetic analysis revealed that all five gene segments of SAG99 analyzed in the present study were most similar to those of the recent Yamagata/16/88‐like viruses. The hemagglutinin and neuraminidase proteins of SAG99 were each distinguished from those of recent epidemic strains by one characteristic amino acid substitution. These substitutions were not found in the previously reported encephalopathy/encephalitis‐derived influenza B viruses, and we could not find any common characteristic amino acid changes in SAG99 and these viruses. Similarly, among the internal proteins studied, only the M2 protein of SAG99 was found to contain a single novel amino acid change when compared with other recent isolates. Thus, it was apparent that SAG99 contained very few amino acid differences when compared with other epidemic viruses. The association of recent B/Yamagata/16/88‐like viruses with encephalitis/encephalopathy observed in the present study and previously suggest that these viruses may have a higher potential for causing neurological complications in certain individuals. J. Med. Virol. 65:590–597, 2001. © 2001 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name></region><name sortKey="Funatsumaru, Sadayuki" sort="Funatsumaru, Sadayuki" uniqKey="Funatsumaru S" first="Sadayuki" last="Funatsumaru">Sadayuki Funatsumaru</name><name sortKey="Lindstrom, Stephen E" sort="Lindstrom, Stephen E" uniqKey="Lindstrom S" first="Stephen E." last="Lindstrom">Stephen E. Lindstrom</name><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name><name sortKey="Nerome, Reiko" sort="Nerome, Reiko" uniqKey="Nerome R" first="Reiko" last="Nerome">Reiko Nerome</name><name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><name sortKey="Shinjoh, Masayoshi" sort="Shinjoh, Masayoshi" uniqKey="Shinjoh M" first="Masayoshi" last="Shinjoh">Masayoshi Shinjoh</name><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name><name sortKey="Shiraishi, Kyoko" sort="Shiraishi, Kyoko" uniqKey="Shiraishi K" first="Kyoko" last="Shiraishi">Kyoko Shiraishi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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